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Taken alongside one another, PEA and its congeners could represent an progressive therapeutic method in the management of mixed neuropathies.This may be of great importance with respect for the catabolism of exogenous PEA if fatty acid binding proteins Participate in a predominant position in its intracellular transportation following its uptake in
Central administration of palmitoylethanolamide reduces hyperalgesia in mice by means of inhibition of NF‐κB nuclear signalling in dorsal root ganglia. Eur J Pharmacol1996). Oral PEA also minimized paw oedema induced by carrageenan, dextran and formalin, suggesting that the compound immediately down‐modulates mast mobile activation in vivoDonv